WHO Approves First Mpox Vaccine

The World Health Organization (WHO) has made a significant advancement in the fight against mpox, a viral disease formerly known as monkeypox. For the first time, the WHO approves the first mpox vaccine, granting it official approval for broader global use. This key development enhances the ability of nations to respond effectively to outbreaks of mpox and provides a crucial tool in public health management.[10]

Approval of MVA-BN Vaccine

The WHO has approved Bavarian Nordic’s MVA-BN as the first mpox vaccine. While mpox is closely related to smallpox, it is generally less severe. The disease spreads through close contact and often presents with flu-like symptoms and a rash. Although not as deadly as smallpox, mpox can still lead to severe illness and complications, particularly in individuals with weakened immune systems.

Importance of WHO’s Prequalification Process

The WHO’s prequalification process is vital because it ensures vaccines meet international safety, efficacy, and quality standards. When a vaccine receives prequalification, global health organizations, governments, and other partners can confidently implement it in large-scale immunization programs. This accelerates vaccine availability in areas that need it most, especially low- and middle-income countries.

Impact of the New Vaccine

The newly prequalified vaccine serves as a crucial tool for controlling mpox. This marks the WHO’s approval of the first mpox vaccine specifically for this disease. With this prequalification, countries can distribute the vaccine more widely, stockpiling doses to prepare for potential future outbreaks. This is particularly important as mpox has re-emerged in various regions, posing a public health threat.

Effectiveness of the Vaccine

The WHO estimates that a single dose of the MVA-BN vaccine offers 76% effectiveness in protecting individuals against mpox, with a second dose potentially increasing effectiveness to 82%. This immunization also proves effective against smallpox and other orthopoxviruses across all adult populations.

Recommendations for Use

The WHO recommends using the MVA-BN vaccine “off-label” for infants, children, adolescents, pregnant individuals, and those with compromised immune systems during outbreaks, provided the benefits outweigh the potential risks.

Preparedness for Outbreaks

Having a prequalified vaccine allows nations to respond more rapidly to outbreaks. In areas where mpox is endemic or where there is a high risk of transmission, this vaccine will play a vital role in reducing the spread of the virus. It will also safeguard those most at risk, such as healthcare workers and individuals in close contact with infected persons.

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Global Collaboration for Vaccine Distribution

As more countries gain access to the vaccine, the global community will be better equipped to manage and prevent future cases of mpox. The WHO’s approval of the first mpox vaccine means that the organization will continue collaborating with governments, vaccine manufacturers, and health organizations to ensure the vaccine reaches those who need it most.

Conclusion

The WHO approves the first mpox vaccine as a breakthrough in global health, offering hope for improved management and protection against a disease that has raised global concerns. With this new vaccine, we move one step closer to controlling mpox and preventing future outbreaks.